• Drugs that affect presynaptic mechanisms
  • botulinum toxin (from the bacterium Clostridium botulinum, an anaerobic bacterium found in the soil): blocks docking by enzymatically cleaving synaptobrevin.
  • tetanus toxin (from the bacterium Clostridium tetani, an anaerobic bacterium found in the soil) blocks docking by enzymatically cleaving synaptobrevin.
  • a-latrotoxin (from black widow spider venom): causes massive release of neurotransmitter (affects neurexin)
  • hemicholinium: blocks the reuptake of choline into the presynaptic nerve terminal