Figure 5.13 The generation of an EPSP. (a) An impulse arriving in the presynaptic terminal causes the release of neurotransmitter. (b) The molecules bind to transmitter-gated ion channels in the postsynaptic membrane. If Na+ enters the postsynaptic cell through the open channels, the membrane will become depolarized. (c) The resulting change in membrane potential (Vm), as recorded by a microelectrode in the cell, is the EPSP.