Figure 5.14 The generation of an IPSP. (a) An impulse arriving in the presynaptic terminal causes the release of neurotransmitter. (b) The molecules bind to transmitter-gated ion channels in the postsynaptic membrane. If Cl- enters the postsynaptic cell through the open channels, the membrane will become hyperpolarized Because ECl is more negative than Vm of the resting membrane. (c) The resulting change in membrane potential (Vm) as recorded by a microelectrode in the cell, is the IPSP.