Pharmacokinetic Study of Theophylline
SUMMARY:
Data from a study by Dr. Robert Upton of the kinetics of the anti-asthmatic drug Theophylline. Twelve subjects were given oral doses of Theophylline then serum concentrations were measured at 11 time points over the next 25 hours.
DATA DESCRIPTION:
This data frame contains the following columns:
Subject:
a factor identifying the subject.
Wt:
weight of the subject (kg).
Dose:
dose administered to the subject (mg/kg).
time:
time since drug administration when the sample was drawn (hours).
conc:
Theophylline concentration in the sample (mg/L).
SOURCE:
These data are reported in Boeckmann, Sheiner, and Beal (1992), "NONMEM User's Guide, Part V, Introductory Guide", University of California, San Francisco and in Davidian and Giltinan (1995), "Nonlinear Models for Repeated Measurement Data", Chapman and Hall, London.
SEE ALSO:
first.order.log , nlme , nlsList , Theoph.plot .
EXAMPLES: 
Theoph.lis <- nlsList(conc ~ first.order.log(Dose, time, lCl, lka, lke),
                    data = Theoph, cluster = ~ Subject)
Theoph.nlme <- nlme(Theoph.lis)